Fifty grams of activated charcoal are instilled by NG tube into the stomach. She undergoes immediate endotracheal intubation with moderate hyperventilation, and receives a 2 liters bolus of normal saline. Her blood pressure is 90 mm Hg by palpation and her heart rate is 110 beats/min. She is somnolent with a Glasgow coma score (GCS) of 8. Case presentationĪ 28 year-old woman with a history of depression is brought to the emergency department approximately one hour after an overdose of amitriptyline. The rationale for its use can be divided into several distinct categories, and its method of administration depends on its clinical indication. ​Sodium bicarbonate administration is a suggested treatment modality for a variety of toxicologic and nontoxicologic conditions such as poisonings by tricyclic antidepressants, toxic alcohols, and salicylates, and other conditions such as hyperkalemia.
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